NARCOTICS

NARCOTICS: 
                          A substance used to treat moderate to severe pain. Narcotics are like opiates such as morphine and codeine, but are not made from opium. They bind to opioid receptors in the central nervous system. Narcotics are now called opioids.



NECROSIS:
                    Necrosis is defined as generalized depression in biological activity due to the presence of toxicant molecules present in the organism.
According to toxicology, narcosis is a toxicity resulting from chemicals associating with and disrupting the lipid bilayer of membranes.
Narcotics are classified into both non-polar(class-1) or polar (class-2) compounds.Members of both classes' compounds are lipid-soluble.
Class 2 compounds contain components that provide some charge distribution(i,e. Aliphatic and aromatic amines, nitroaromatics, and alcohols ).

The aliphatic hydrocarbons (c5 through c8) are examples of powerful class 1 narcotics, whereas ethanol is an example of a class 2 narcotic.
Attachment of the drug partition to the polar-free core of the membrane (Class 1 narcotics) or to be distributed in the polar and nonpolar parts of the membrane (Class 2 narcotics) changes the fluidity of the membranes.
This effect compromises the ability of proteins and other components of the membrane to function properly, leading to different types of narcosis
The central nervous system is the prime target of chemical narcosis and symptoms initially include disorientation,  euphoria, giddiness, and progress to unconsciousness, convulsion, and death.

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